Prof. Neta Regev-Rudzki, from the Department of Biomolecular Sciences, Weizmann Institute of Science, Israel, is leading a lab focused on the biology of Plasmodium falciparum– the malaria parasite the causing agent of the most devastating parasitic disease. Upon completing her postdoctoral training at the Walter and Eliza Hall Institute (WEHI) in Melbourne, Australia, she opened her lab in 2015. Her pioneering work centers on the communication mechanisms of the parasite through the secretion of extracellular vesicles (EVs) and their contents, which comprise an array of bioactive molecules, such as proteins, lipids, glycans, RNA, and DNA. This is a relatively new area of malaria research and only little is currently known about EV cargo delivery as well as functions, in particularly in mediating pathogen-host interaction. By delving into the cellular mechanisms that the parasites employ, she has unlocked the mystery of how they communicate with their two different host systems - the immune system and the red blood cells. These findings have the potential to open up a new therapeutic avenue in the fight against malaria.